WB V-B

One cause of brain cell death is glutamate toxicity. Brain cells use
glutamate as a neurotransmitter, but unfortunately glutamate is a
double-edged sword in that it can also kill brain cells. The release of
glutamate from the synapses is a usual means by which neurons
communicate with each other.

57 minutes ago · Comment ·

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    Panda Man Effective communication means controlled release of glutamate at the right time to the right cells, but when glutamate is released in excessive amounts, intercellular communication ceases. The flood of glutamate into the receiving neurons drives them into hyperactivity, and the excessive activity leads to cellular degradation.

    57 minutes ago ·
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    Panda Man The good news is that it may now be possible to protect brain cells against glutamate toxicity by taking methylcobalamin supplementation. In a study in the European Journal of Pharmacology, it was shown that methylcobalamin protected against glutamate-, aspartate- and nitroprusside- induced neurotoxicity in rat cortical neurons.

    56 minutes ago ·
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    Panda Man Researchers concluded that methylcobalamin protects against neurotoxicity by enhancing brain cell methylation. The CFIDS & Fibromyalgia Health Resource recommends

    methylation-enhancing therapies such as vitamin B6, vitamin B-12, folic acid and trimethylglycine (TMG)

    , taken together, to protect against heart disease, stroke and other aging-related diseases.

    56 minutes ago ·
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    Panda Man The scientists who conducted the methylcobalamin studies emphasize that ongoing intake of methylcobalamin is necessary to protect against neurotoxicity. Thus for methylcobalamin to be effective in protecting against neurological disease, daily supplementation may be required.

    55 minutes ago ·
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    Panda Man

    Sleep
    A recent German study appearing in Neuropharmacology showed methylcobalamin reduced the amount of time subjects slept; sleep quality was better and subjects awoke feeling refreshed, with better alertness and concentration. Part of this effect was apparently due to melatonin suppression during the daytime because morning methylcobalamin supplementation reduces drowsiness by decreasing daytime melatonin levels.